Mr Kent is a 45-year-old African American male with a history of Type 2 diabetes hypertension and hyperlipidemia

Mr Kent is a 45-year-old African American male with a history of Type 2 diabetes hypertension and hyperlipidemia

Mr. Kent is a 45-year-old African American male with a history of Type 2 diabetes, hypertension, and hyperlipidemia. His renal function has slowly decreased over the past 4 years and his nephrologist has told him that his GFR has decreased to 15cc ml/min and will soon need renal dialysis for chronic renal failure.

Question:

How does chronic renal failure develop?